Privileged Structures for Protein Binding

Privileged Structures for Protein Binding
from an Analysis of NMR-Based Screening

Hajduk, P. J.; Bures, M.; Praestgaard, J.; Fesik, S. W. J. Med. Chem. 2000, 43, 3443-3447.

- 11 protein targets: "(1) E2-DBD: the DNA-binding domain of the human papillomavirus E2 protein. (2) the matrix metalloproteinase stromelysin. (3) VEGF: the receptor binding domain of the vascular endothelial growth factor. (4) the FK-506 binding protein. (5) the Src homology-2 domain of p56^lck. (6) the methyl transferase ErmAM. (7) the DNA-binding domain of NFATc. (8) the peptidyl prolyl cis-trans isomerase Pin-1. (9) the anti-apoptic protein Bcl-xL. (10) the anti-apoptic protein Bcl-2. (11) the phosphotyrosyl phosphatase PTB-1B.

- Ligand binding detected by ¹⁵N/¹H-HSQC spectra in DMSO.